Automated NMR Fragment Based Screening Identified a Novel Interface Blocker to the LARG/RhoA Complex
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منابع مشابه
Automated NMR Fragment Based Screening Identified a Novel Interface Blocker to the LARG/RhoA Complex
The small GTPase cycles between the inactive GDP form and the activated GTP form, catalyzed by the upstream guanine exchange factors. The modulation of such process by small molecules has been proven to be a fruitful route for therapeutic intervention to prevent the over-activation of the small GTPase. The fragment based approach emerging in the past decade has demonstrated its paramount potent...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0088098